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nanoScan® SPECT/CT

SPECT/MRI and SPECT/CT/PET

Versatile SPECT/CT with absolute quantification and full stationary dynamic imaging

The nanoScan® SPECT system images radiotracers with absolute quantification, high sensitivity and high spatial resolution down to 0.3 mm in vivo.

Wide range of patented multi-pinhole collimators available with optimized performance for any applications: from whole-body to focused scanning; imaging of mice, multiple mice, large rats and rabbits; from low energy tracers to theranostic isotopes. Best homogeneity on the market is achieved by helical scanning, while fastest 3D dynamic acquisitions are carried out in full stationary mode without gantry or table motion.

The SPECT system is also available in triple-modality combination with our high-end PET systems (see nanoScan SPECT/CT/PET).

Features & Benefits

High sensitivity and high resolution simultaneously

  • Proprietary and patented multi-pinhole collimator technology offering excellent spatial resolution, high sensitivity and large field of view at the same time
  • Cutting-edge sensitivity even for high-energy isotopes ensured by 9.5 mm thick sodium iodide (NaI:Tl) crystals with large area and minimal detector gaps
  • Exclusive imaging performance with ultra-low activity

Absolute quantitative SPECT imaging

  • Tera-Tomo™ 3D SPECT reconstruction: iterative SPECT reconstruction engine based on real-time Monte Carlo simulation
  • Full range of advanced corrections
  • CT- or MRI-based attenuation and scatter correction
  • Excellent homogeneity by helical scanning for comparison of regional uptakes
  • Time-Activity Curve (TAC) generation and calculation of Standardized Uptake Values (SUV)

Fast dynamic SPECT with Full Stationary imaging

  • PET-like dynamic imaging capability with list mode data storage
  • Completely motionless acquisition providing time-continuous data from the whole cross-section of the animal
  • 3D quantitative dynamic imaging with 1-3 second time frames
  • Time-Activity Curve generation from 3D quantitative results.

Largest Field of View for large or multiple animal imaging

  • Large detector field of view:
    27 cm x 27 cm (10.6” x 10.6”)
  • Wide gantry opening: up to 27 cm
  • Various animal models from tiny mouse to large rabbits (6.5 kg / 14.3 lb)
  • Multiple mouse imaging chamber with physiological monitoring feature for all animals
  • Wide range of collimation techniques and collimators: Single-Pinhole, Multi-Pinhole and Parallel-hole.

Imaging of Multiple and Theranostic isotopes

  • Dedicated multi-pinhole collimators for high-energy imaging
  • List-mode data acquisition for simultaneous imaging of multiple isotopes, even for simultaneous scanning of PET and SPECT tracers
  • 9.5 mm thick NaI:Tl crystals ensuring high sensitivity for high-energy gamma photons
  • Imaging of theranostic isotopes like 131I, 213Bi, 225Ac and more

High power CT with large field of view and high resolution

  • Up to 80 W X-ray power enables high-performance scanning even for large or multiple animals
  • Variable magnification for high-resolution imaging with 10 μm isotropic voxel size
  • Very high throughput: fast scanning with real-time image reconstruction combined with multiple animal imaging capability
  • Iterative image reconstruction for low-noise and low-dose imaging
  • Ultra-low-dose protocol for follow-up studies with only 1 mSv whole-body dose to the animal
  • Imaging with cardiac and respiratory gating

Applications

Quantitative imaging of 125I in rabbit

CT based attenuation and scatter correction allows absolute quantification even at low energy with I-125 isotope imaging in rabbit.

  • Animal: 2.5 kg (5.5 lb) New Zealand White (NZW) rabbit
  • Radiotracer:

37 MBq (1 mCi) and 17.5 MBq (0.5 mCi) 125I-hyaluronic acid injected into the left and right articular cavity respectively

  • Collimator:

low-energy ultra-high-resolution (LEUHR)

  • Acquisition: circular SPECT

High-resolution bone imaging in mouse

The ultra-high-resolution multi-pinhole collimator can visualise the finest details of the mouse skeleton: individual vertebrae and ribs; radius and ulna bones in the forearms.

  • Animal: 20 g mouse
  • Radiotracer: 37 MBq (1 mCi) 99mTc - MDP
  • Collimator:

ultra-high-resolution multi-pinhole for whole-body mouse imaging

  • Acquisition: helical SPECT

Theranostics: imaging with Lu-177 in mouse

Dedicated high-energy multi-pinhole collimator allows imaging of theranostic tracers like 177Lu.

  • Animal: 18 g mouse
  • Radiotracer: 34.48 MBq (931 µCi) 177Lu
  • Collimator:

high-sensitivity and high-resolution multi-pinhole for whole-body mouse imaging

  • Acquisition: helical SPECT

Theranostics: imaging with I-131 in mouse

Dedicated high-energy multi-pinhole collimator allows imaging of theranostic tracers like 131I.

  • Animal: 18 g mouse
  • Radiotracer: 2.5 MBq (68 µCi) 131I - albumin
  • Collimator:

high-energy multi-pinhole for whole-body mouse imaging

  • Acquisition: helical SPECT

High resolution bone imaging in rat

The high-resolution multi-pinhole collimator can visualise the finest details of the rat skeleton: individual vertebrae and ribs; radius and ulna bones in the forearms.

  • Animal: 320 g Wistar rat
  • Radiotracer: 120 MBq (3.2 mCi) 99mTc - MDP
  • Collimator:

high-resolution multi-pinhole for whole-body rat imaging

  • Acquisition: helical SPECT

Simultaneous imaging of three mice

Large single-bed-position field of view and high sensitivity allow three mouse imaging routinely resulting in unprecedented throughput.

  • Animal: 3x 20g mice
  • Radiotracer:

16.6 - 18.7 MBq (450-500 µCi) 99mTc - pertechnetate

  • Collimator:

high-sensitivity and high resolution multi-pinhole for whole-body rat imaging

  • Acquisition: helical SPECT

Publications

2024.01.05.

Effects of isoflurane anaesthesia depth and duration on renal function measured with [99mTc]Tc-mercaptoac...

Fabian Schmitz-Peiffer et al., EJNMMI Res., 2024
View publication
2023.10.04.

Myoglobin-loaded gadolinium nanotexaphyrins for oxygen synergy and imaging-guided radiosensitization ther...

Xiaotu Ma et al, Nat Commun. 2023
View publication
2023.09.26.

[225Ac]Ac- and [111In]In-DOTA-trastuzumab theranostic pair: cellular dosimetry and cytotoxicity in vitro...

Misaki Kondo, Zhongli Cai, Conrad Chan, Nubaira Forkan, and Raymond M. Reilly EJNMMI Radiopharm Chem, 20...
View publication
2023.08.14.

Sensitive, non-immunogenic in vivo imaging of cancer metastases and immunotherapy response

Joseph R. Merrill, Alessandra Inguscio,Taemoon Chung, Breanna Demestichas, Libia A. Garcia, Jill Habel, D...
View publication
2023.04.19.

A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development...

Darja Beyer et al., 2023, EJNMMI Research
View publication
2022.05.11.

Preclinical Investigations to Explore the Difference between the Diastereomers [177Lu]Lu-SibuDAB and [177...

Francesca Borgna, Luisa M. Deberle, Sarah D. Busslinger, Viviane J. Tschan, Laura M. Walde, Anna E. Becke...
View publication
2021.04.12.

Simultaneous Visualization of 161Tb- and 177Lu-Labeled Somatostatin Analogues Using Dual-Isotope SPECT Im...

Francesca Borgna et al., MDPI Pharmaceutics, 2021
View publication
2020.09.21.

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mou...

Tobias Gustavsson et al., Translational Neurodegeneration, 2020
View publication
2020.05.07.

Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1

Anzhelika Vorobyeva et al., International Journal of Molecular Sciences, 2020
View publication
All publications

Images

Specification

SPECT
CT
MRI
Gantry opening
up to 27 cm
Animal models
mouse, rat, marmoset, guinea pig, rabbit (up to 6.5kg), monkey
Multiple animal imaging
up to 3 x 60 g mice
Detector crystal
9.5 mm NaI(Tl)
Spatial resolution
down to 0.3 mm
Sensitivity
up to 13 000 cps/MBq
Energy range
from 125I to theranostic and PET isotopes
Collimators
Wide range of: Multi-pinhole; Single-pinhole; Parallel-hole collimators
Dynamic imaging
Yes, ultra-fast 4D/5D list mode dynamic imaging by static or rotational SPECT
Acquisition schemes
SPECT (3D): helical, circular, semi-stationary and full stationaryPlanar (2D): static, dynamic
X-ray power
up to 80 W
Gantry opening
16 cm
Transaxial FOV
12 cm
Axial FOV
10 cm
Animal models
mouse, rat, marmoset, guinea pig, rabbit
Multiple animal imaging
up to 3 x 60 g mice
Image reconstruction
modified Feldkamp-type for real-time reconstruction,iterative reconstruction for low-dose and low-noise applications
Spatial resolution
30 μm at 10 μm voxel size
Low-dose protocol
down to 1 mSv for whole-body mouse
Magnet
Maintenance-free permanent magnet with 1 Tesla field strength
Magnetic fringe field
Zero (5 Gauss line is inside the cover)
Shielding
Integrated RF shielding, no need for Faraday cage
RF Coils
Volume coils: whole-body mouse, whole-body rat Surface coils: mouse brain, rat brain
Spatial resolution
100 μm in vivo<100 µm ex vivo

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