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nanoScan® PET/MRI 3T and 7T

Full-scale, quantitative PET combined with a robust, cryogen-free MRI

The new nanoScan® systems follow the footsteps of the first ever commercially available integrated preclinical PET/MRI system introduced by Mediso in 2011. The new nanoScan® PET/MRI systems are now equipped with both high end PET with simultaneous capability and state-of-the-art superconducting MRI subsystems.

The in-line PET subsystem features real dynamic scanning with the best count rate performance and highest resolution on the market, designed for quantitative imaging of mice, rats and even larger animals. When complemented with the PET insert the system covers every possible application in molecular imaging.

The MRI subsystems equipped with robust cryogen-free superconducting translational 3T and ultra-high field 7T magnets enable high end in vivo imaging applications.

Features & Benefits

Dual PET Configuration

Simultaneous or sequential? The dual PET configuration offers the best performance for all PET/MRI studies

  • Full-scale PET-ring on the front guarantees unlimited quantitative imaging regardless the amount of radioactivity, acquisition time or animal size.
  • SiPM-based PET insert ensures simultaneous PET/MRI studies without any interference between the PET and MRI readout.

In-line PET: highest-resolution, large diameter PET-subsystem with the widest dynamic range

  • High performance, market leading PET identical with the one used in the nanoScan® PET/CT
  • Finest lutetium oxyorthosilicate (LYSO) crystal needles in a large-diameter ring and statistical depth of interaction (DOI) compensation offer highest resolution and homogeneous image quality over the entire field of view
  • Bore size and transaxial field of view enabling scanning of larger rats or multiple mice in both PET and MRI
  • Best minimal detectable activity on the market: 60 Bq (1.6 nCi)
  • Inherently optimized for longitudinal studies e.g. long-term cell tracking
  • Fully quantitative at 60 MBq (1.6 mCi) and beyond
  • Optimal for imaging of isotopes with short half-life (11C, 13N, 15O etc.)

PET insert offering simultaneous multiparametric imaging

Due to the high level of integration the nanoScan® PET insert offers uncompromised image quality while giving access to a unique way of hybrid imaging by obtaining information from functional, metabolic and physiological processes in a simultaneous manner. 

  • Simultaneous PET/MRI imaging of total body mouse or rat brain
  • Providing high resolution and homogeneous image quality over the entire field of view as a result of using the finest LYSO crystal needles and statistical depth of interaction compensation
  • Removable, allowing access to the full-bore of the MRI and also making benchtop measurements possible
  • Available as an upgrade for existing PET/MRI 3T, 7T and MRI 3T, 7T installations or as a standalone system

Perfect Integration of PET and MRI

Complete PET/MRI workflow

  • Innovative gantry design enables perfect animal positioning resulting in accurate co-registered images
  • Using the rotatable touchscreen it is possible to start dynamic PET or MRI measurements right from the scanner opening. The same touchscreen can be used for easy tuning and matching of Tx/Rx volume coils.
  • The software suite developed by Mediso covers the complete workflow from image acquisition, attenuation correction and reconstruction to image fusion and analysis, without the need of any third party software.

Ultra low attenuation Brain imaging coils

  • We designed our brain array coils with special care to achieve the lowest possible attenuation at 511KeV.
  • Using the 2ch phased array coil excellent contrast can be achieved in the brain region with uncompromised PET performance.

Robust cryogen-free magnet

The core of the nanoScan® MRI systems is the most robust cryogen-free superconducting magnet ever built for preclinical applications. Uniquely on the market it features a back mounted cryocooler to reduce conducted vibrations and make maintenance easier.

  • The magnet uses conduction cooling to reach superconducting temperatures therefore the magnet is 100% cryogen-free thus does not require quench pipes or any cryogen filling.
  • No Faraday cages are needed as the magnet is self-shielded. Due to its unique design the scanner is tightly sealed during operation allowing for ultra-low noise conditions.
  • Its base is a NbTi solenoid with multiple corresponding coils to maximize homogeneity and shielding thus reaching state-of-the-art homogeneity of ±0.1 ppm @ 50 mm DSV and negligible fringe field outside the cryostat.
  • Transport from loading dock and siting in a relatively small space is easily accomplished, as the magnet is very light (<250kg) with a small, sleek footprint.

Applications

Images

Specification

In-line PET
PET insert
3T MRI
7T MRI
Bore size
16 cm
Transaxial FOV
12 cm
Axial FOV
10 cm
Animal models
mouse, rat, marmoset, guinea pig
Multiple animal imaging
up to 3 mice or 2 rats
LSO crystal size
LSO (1.12 x 1.12 x 13 mm)
Spatial resolution with Tera-Tomo (3D OSEM)
0.7 mm
Spatial Resolution with FBP (NEMA)
1.25 mm
Sensitivity
8 %
Noise Equivalent Count Rate for mouse (NEMA)
850 kcps @ 60 MBq / 1.65 mCi
Noise Equivalent Count Rate for rat (NEMA)
250 kcps @ 60 MBq / 1.65 mCi
Bore size
5.4 cm
Transaxial FOV
4.5 cm
Axial FOV
10 cm
Animal models
Mouse whole-body, rat brain
LSO crystal size
LSO (1.12 x 1.12 x 8 mm)
Spatial resolution with Tera-Tomo (3D OSEM)
0.9 mm
Sensitivity
7 %
Magnet
Cryogen-free superconducting
Field strength
3T
Bore size
17 cm
Cryocooler
Back-mounted Pulse Tube
Homogeneity
±0.1 ppm @ 50 mm DSV
Quench protection
Yes, with SmartMagnet™
Gradient coil inner diameter
101mm
Gradient strength
Up to 1000 mT/m
Rampable
Yes
Faraday cage needed?
NO the system is self-shielded
Quench pipe needed?
No the system is 100% cryogen-free
Magnet
Cryogen-free superconducting
Field strength
7T
Bore size
17 cm
Cryocooler
Back-mounted Pulse Tube
Homogeneity
±0.1 ppm @ 50 mm DSV
Quench protection
Yes, with SmartMagnet™
Gradient coil inner diameter
101 mm
Gradient strength
Up to 1000 mT/m
Rampable
Yes
Faraday cage needed?
NO the system is self-shielded
Quench pipe needed?
No the system is 100% cryogen-free

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