Please select your language:
Vidya Narayanaswami et al., Springer Open EJNMMI Radiopharmacy and Chemistry, 2020
Summary
Clinical importance of 5-HT1A receptors in the pathogenesis of several psychiatric and neurodegenerative disorders has promoted development of carbon-11 and fluorine-18 labeled radiotracers for in vivo positron emission tomography (PET). The gold standard PET imaging agent limited its widespread use.
The purpose of the current study was to develop and characterize a radioligand with suitable characteristics for imaging 5-HT1A receptors in the brain. The authors have reported the in vitro pharmacological characterization, radiosynthesis and preliminary in vivo PET imaging of three new 5-HT1A receptor arylpiperazine based ligands in rats (DF-100 (1), DF-300 (2) and DF-400 (3)).
They concluded DF-400 represents a promising O-methylated lead candidate which if subjected to structural alterations, may either lead to improved selectivity for 5-HT1A receptors or may assist in the development of the first PET radioligand for α1-adrenergic receptors.
Results from nanoScan PET/MRI 3T
Fig. 2 Uptake of [11C]3 (a); [11C]2 (b) and [11C]1 (c) in rat brain. Shown are TACs averaged for left and right brain (A: n = 3; B and C: n = 1) in SUV and summed (0–60 min) PET images in coronal, transverse and sagittal planes, respectively, through the thalamus. The spatially co-registered MR images (2D fast spin echo) show left-half ROIs including thalamus (blue), anterior cingulate cortex (red), hippocampus (green) and cerebellum (magenta) for the corresponding color-coded TACs
Fig. 2 Blocking of the uptake of [11C]3 in rat brain by WAY-100635 (a) and prazosin (b). Shown are TACs, averaged for left and right brain, (n = 1; solid: baseline; dashed: blocking) in SUV and summed (0–60 min) PET images in coronal, transverse and sagittal planes, respectively, through the thalamus at baseline and under blocking conditions. The three depicted left-half ROIs include thalamus (orange), hippocampus (red) and cerebellum (magenta) for the corresponding color-coded TACs
Article: https://ejnmmipharmchem.springeropen.com/articles/10.1186/s41181-020-00096-8
High-end MRI with the most robust cryogen-free superconducting magnet on the mar...
Real dynamic PET-system designed for quantitative studies
Full-scale, quantitative PET combined with a robust, cryogen-free MRI
Versatile SPECT with Real dynamic PET with absolute quantification
Don't hesitate to contact us for technical information or to find out more about our products and services.
Get in touchPlease accept our cookies!
Our website uses cookies so we can provide you the best experience while using our site. By using our website you accept our Privacy Policy and our Terms of Use.